Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities

The signaling lipid phosphatidylinositol (3,4,5)-trisphosphate (PIP3) is a key regulator of cell proliferation, survival, and migration and the enzyme that dephosphorylates it, phosphatase and tensin homolog (PTEN), is an important tumor suppressor. As excess PIP3 signaling is a hallmark of many can...

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Bibliografiske detaljer
Main Authors: Nguyen, Hoai-Nghia, Yang, Jr-Ming, Afkari, Yashar, Park, Ben Ho, Sesaki, Hiromi, Devreotes, Peter N., Iijima, Miho
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084459/
https://ncbi.nlm.nih.gov/pubmed/24979808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409433111
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