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Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN

By limiting phosphotidylinositol 3,4,5-triphosphate (PIP(3)) levels, tumor suppressor PTEN not only controls cell growth but also maintains cell polarity required for cytokinesis and chemotaxis. To identify the critical targets of PIP(3) that link it to the cytoskeleton, we deleted secondary genes t...

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Hlavní autoři: Tang, Ming, Iijima, Miho, Kamimura, Yoichiro, Chen, Lingfeng, Long, Yu, Devreotes, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038642/
https://ncbi.nlm.nih.gov/pubmed/21169559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-06-0522
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