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Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN

By limiting phosphotidylinositol 3,4,5-triphosphate (PIP(3)) levels, tumor suppressor PTEN not only controls cell growth but also maintains cell polarity required for cytokinesis and chemotaxis. To identify the critical targets of PIP(3) that link it to the cytoskeleton, we deleted secondary genes t...

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Detalhes bibliográficos
Main Authors: Tang, Ming, Iijima, Miho, Kamimura, Yoichiro, Chen, Lingfeng, Long, Yu, Devreotes, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038642/
https://ncbi.nlm.nih.gov/pubmed/21169559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-06-0522
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