PLA(2) and PI3K/PTEN pathways act in parallel to mediate chemotaxis

Directed cell migration involves signaling events that lead to local accumulation of PI(3,4,5)P(3) but additional pathways act in parallel. A genetic screen in Dictyostelium discoideum to identify redundant pathways revealed a gene with homology to patatin-like phospholipase A(2). Loss of this gene...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Lingfeng, Iijima, Miho, Tang, Ming, Landree, Mark A., Huang, Yi Elaine, Xiong, Yuan, Iglesias, Pablo A., Devreotes, Peter N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986835/
https://ncbi.nlm.nih.gov/pubmed/17419997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2007.03.005
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