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Two Complementary, Local Excitation, Global Inhibition Mechanisms Acting in Parallel Can Explain the Chemoattractant-Induced Regulation of PI(3,4,5)P(3) Response in Dictyostelium Cells

Chemotaxing cells, such as Dictyostelium and mammalian neutrophils, sense shallow chemoattractant gradients and respond with highly polarized changes in cell morphology and motility. Uniform chemoattractant stimulation induces the transient translocations of several downstream signaling components,...

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Detalles Bibliográficos
Main Authors: Ma, Lan, Janetopoulos, Chris, Yang, Liu, Devreotes, Peter N., Iglesias, Pablo A.
Formato: Artigo
Idioma:Inglês
Publicado: Biophysical Society 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304889/
https://ncbi.nlm.nih.gov/pubmed/15465874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.045484
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