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Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

In chemotactic cells, G protein–coupled receptors activate Ras proteins, but it is unclear how Ras-associated pathways link extracellular signaling to cell migration. We show that, in Dictyostelium discoideum, activated forms of RasC prolong the time course of TORC2 (target of rapamycin [Tor] comple...

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Autors principals: Cai, Huaqing, Das, Satarupa, Kamimura, Yoichiro, Long, Yu, Parent, Carole A., Devreotes, Peter N.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930282/
https://ncbi.nlm.nih.gov/pubmed/20660630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201001129
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