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PIP3-independent activation of TorC2 and PKB at the cell’s leading edge mediates chemotaxis
BACKGROUND: Studies show that high phosphotidylinositol 3,4,5 tris phosphate (PIP(3)) promotes cytoskeletal rearrangements and alters cell motility and chemotaxis, possibly through activation of PKBs. However, chemotaxis can still occur in the absence of PIP(3) and the identities of the PIP(3) indep...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018231/ https://ncbi.nlm.nih.gov/pubmed/18635356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2008.06.068 |
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