Variation in the Circumsporozoite Protein of Plasmodium falciparum: Vaccine Development Implications

The malaria vaccine candidate RTS,S/AS01 is based on immunogenic regions of Plasmodium falciparum circumsporozoite protein (CSP) from the 3D7 reference strain and has shown modest efficacy against clinical disease in African children. It remains unclear what aspect(s) of the immune response elicited...

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Autori principali: Gandhi, Kavita, Thera, Mahamadou A., Coulibaly, Drissa, Traoré, Karim, Guindo, Ando B., Ouattara, Amed, Takala-Harrison, Shannon, Berry, Andrea A., Doumbo, Ogobara K., Plowe, Christopher V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081809/
https://ncbi.nlm.nih.gov/pubmed/24992338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101783
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