Variation in the Circumsporozoite Protein of Plasmodium falciparum: Vaccine Development Implications

The malaria vaccine candidate RTS,S/AS01 is based on immunogenic regions of Plasmodium falciparum circumsporozoite protein (CSP) from the 3D7 reference strain and has shown modest efficacy against clinical disease in African children. It remains unclear what aspect(s) of the immune response elicited...

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Detalhes bibliográficos
Main Authors: Gandhi, Kavita, Thera, Mahamadou A., Coulibaly, Drissa, Traoré, Karim, Guindo, Ando B., Ouattara, Amed, Takala-Harrison, Shannon, Berry, Andrea A., Doumbo, Ogobara K., Plowe, Christopher V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081809/
https://ncbi.nlm.nih.gov/pubmed/24992338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101783
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