Variation in the circumsporozoite protein of Plasmodium falciparum: vaccine development implications.

The malaria vaccine candidate RTS,S/AS01 is based on immunogenic regions of Plasmodium falciparum circumsporozoite protein (CSP) from the 3D7 reference strain and has shown modest efficacy against clinical disease in African children. It remains unclear what aspect(s) of the immune response elicited...

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Autors principals:	Kavita Gandhi, Mahamadou A Thera, Drissa Coulibaly, Karim Traoré, Ando B Guindo, Amed Ouattara, Shannon Takala-Harrison, Andrea A Berry, Ogobara K Doumbo, Christopher V Plowe
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2014-01-01
Col·lecció:	PLoS ONE
Accés en línia:	https://doi.org/10.1371/journal.pone.0101783
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