Next Generation Sequencing to Detect Variation in the Plasmodium falciparum Circumsporozoite Protein

The malaria vaccine RTS,S/AS01, based on immunogenic regions of the Plasmodium falciparum circumsporozoite protein (CSP), has partial efficacy against clinical malaria in African children. Understanding how sequence diversity in CSP T- and B-cell epitopes relates to naturally acquired and vaccine-in...

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Main Authors: Gandhi, Kavita, Thera, Mahamadou A., Coulibaly, Drissa, Traoré, Karim, Guindo, Ando B., Doumbo, Ogobara K., Takala-Harrison, Shannon, Plowe, Christopher V.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Tropical Medicine and Hygiene 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335679/
https://ncbi.nlm.nih.gov/pubmed/22556073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.2012.11-0478
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