Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

Marrow stromal cells (MSCs) provide important survival and drug resistance signals to chronic lymphocytic leukemia (CLL) cells, but current models to analyze CLL–MSC interactions are heterogeneous. Therefore, we tested different human and murine MSC lines and primary human MSCs for their ability to...

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Библиографические подробности
Главные авторы: Kurtova, Antonina V., Balakrishnan, Kumudha, Chen, Rong, Ding, Wei, Schnabl, Susanne, Quiroga, Maite P., Sivina, Mariela, Wierda, William G., Estrov, Zeev, Keating, Michael J., Shehata, Medhat, Jäger, Ulrich, Gandhi, Varsha, Kay, Neil E., Plunkett, William, Burger, Jan A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2009
Предметы:
Lymphoid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081374/
https://ncbi.nlm.nih.gov/pubmed/19762485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-233718
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