The microenvironment in hairy cell leukemia: pathways and potential therapeutic targets

per Burger, Jan A., Sivina, Mariela, Ravandi, Farhad
Publicat 2011

The BTK Inhibitor Ibrutinib (PCI-32765) Blocks Hairy Cell Leukaemia Survival, Proliferation and BCR Signalling: A New Therapeutic Approach

per Sivina, Mariela, Kreitman, Robert J., Arons, Evgeny, Ravandi, Farhad, Burger, Jan A.
Publicat 2014

Proteasome inhibitor carfilzomib complements ibrutinib’s action in chronic lymphocytic leukemia

per Lamothe, Betty, Cervantes-Gomez, Fabiola, Sivina, Mariela, Wierda, William G., Keating, Michael J., Gandhi, Varsha
Publicat a Blood (2015)

The transcription factor ELF4 controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow

per Sivina, Mariela, Yamada, Takeshi, Park, Chun Shik, Puppi, Monica, Coskun, Suleyman, Hirschi, Karen, Lacorazza, H. Daniel
Publicat 2011

B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406

per Quiroga, Maite P., Balakrishnan, Kumudha, Kurtova, Antonina V., Sivina, Mariela, Keating, Michael J., Wierda, William G., Gandhi, Varsha, Burger, Jan A.
Publicat a Blood (2009)

Effects of Pharmacological and Genetic Disruption of CXCR4 Chemokine Receptor Function in B-Cell Acute Lymphoblastic Leukaemia

per Randhawa, Shubhchintan, Cho, Byung Sik, Ghosh, Dipanjan, Sivina, Mariela, Koehrer, Stefan, Müschen, Markus, Peled, Amnon, Davis, Richard E., Konopleva, Marina, Burger, Jan A.
Publicat a Br J Haematol (2016)

Long term follow up of treatment with ibrutinib and rituximab (IR) in patients with high-risk Chronic Lymphocytic Leukemia (CLL)

per Jain, Preetesh, Keating, Michael, Wierda, William, Sivina, Mariela, Thompson, Philip A., Ferrajoli, Alessandra, Estrov, Zeev, Kantarjian, Hagop, O'Brien, Susan, Burger, Jan A.
Publicat a Clin Cancer Res (2016)

Dynamic changes in CCL3 and CCL4 plasma concentrations in patients with chronic lymphocytic leukaemia managed with observation

per Sivina, Mariela, Werner, Lillian, Rassenti, Laura, Ferrajoli, Alessandra, Wierda, William G., Keating, Michael J., O’Brien, Susan, Neuberg, Donna, Kipps, Thomas, Burger, Jan A.
Publicat a Br J Haematol (2016)

Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia

per Morande, Pablo Elías, Sivina, Mariela, Uriepero, Angimar, Seija, Noé, Berca, Catalina, Fresia, Pablo, Landoni, Ana Inés, Di Noia, Javier M., Burger, Jan A., Oppezzo, Pablo
Publicat a Blood (2019)

Selective, novel Spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B cell activation and migration

per Hoellenriegel, Julia, Coffey, Greg P., Sinha, Uma, Pandey, Anjali, Sivina, Mariela, Ferrajoli, Alessandra, Ravandi, Farhad, Wierda, William G., O’Brien, Susan, Keating, Michael J., Burger, Jan A.
Publicat a Leukemia (2012)

Ibrutinib therapy increases T cell repertoire diversity in patients with chronic lymphocytic leukemia

per Yin, Qingsong, Sivina, Mariela, Robins, Harlan, Yusko, Erik, Vignali, Marissa, O’Brien, Susan, Keating, Michael J., Ferrajoli, Alessandra, Estrov, Zeev, Jain, Nitin, Wierda, William G., Burger, Jan A.
Publicat a J Immunol (2017)

The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action

per Chen, Rong, Tsai, Jennifer, Thompson, Philip A., Chen, Yuling, Xiong, Ping, Liu, Chaomei, Burrows, Francis, Sivina, Mariela, Burger, Jan A., Keating, Michael J., Wierda, William G., Plunkett, William
Publicat a Blood Cancer J (2021)

The BET Inhibitor GS-5829 Targets Chronic Lymphocytic Leukemia Cells and Their Supportive Microenvironment

per Kim, Ekaterina, ten Hacken, Elisa, Sivina, Mariela, Clarke, Astrid, Thompson, Philip A., Jain, Nitin, Ferrajoli, Alessandra, Estrov, Zeev, Keating, Michael J., Wierda, William G., Bhalla, Kapil N., Burger, Jan A.
Publicat a Leukemia (2019)

The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

per Hoellenriegel, Julia, Meadows, Sarah A., Sivina, Mariela, Wierda, William G., Kantarjian, Hagop, Keating, Michael J., Giese, Neill, O'Brien, Susan, Yu, Albert, Miller, Langdon L., Lannutti, Brian J., Burger, Jan A.
Publicat a Blood (2011)

Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia

per Badoux, Xavier C., Keating, Michael J., Wen, Sijin, Lee, Bang-Ning, Sivina, Mariela, Reuben, James, Wierda, William G., O'Brien, Susan M., Faderl, Stefan, Kornblau, Steven M., Burger, Jan A., Ferrajoli, Alessandra
Publicat 2011

Functional Differences Between IgM and IgD Signaling in Chronic Lymphocytic Leukemia

per Hacken, Elisa ten, Sivina, Mariela, Kim, Ekaterina, O’Brien, Susan, Wierda, William G., Ferrajoli, Alessandra, Estrov, Zeev, Keating, Michael J., Oellerich, Thomas, Scielzo, Cristina, Ghia, Paolo, Caligaris-Cappio, Federico, Burger, Jan A.
Publicat a J Immunol (2016)

Autoimmune cytopenias in patients with chronic lymphocytic leukemia treated with ibrutinib

per Vitale, Candida, Ahn, Inhye E., Sivina, Mariela, Ferrajoli, Alessandra, Wierda, William G., Estrov, Zeev, Konoplev, Sergej N., Jain, Nitin, O’Brien, Susan, Farooqui, Mohammed, Keating, Michael J., Wiestner, Adrian, Burger, Jan A.
Publicat a Haematologica (2016)

The PI3-Kinase Delta Inhibitor Idelalisib (GS-1101) Targets Integrin-Mediated Adhesion of Chronic Lymphocytic Leukemia (CLL) Cell to Endothelial and Marrow Stromal Cells

per Fiorcari, Stefania, Brown, Wells S., McIntyre, Bradley W., Estrov, Zeev, Maffei, Rossana, O’Brien, Susan, Sivina, Mariela, Hoellenriegel, Julia, Wierda, William G., Keating, Michael J., Ding, Wei, Kay, Neil E., Lannutti, Brian J., Marasca, Roberto, Burger, Jan A.
Publicat 2013

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediat...

per Kurtova, Antonina V., Balakrishnan, Kumudha, Chen, Rong, Ding, Wei, Schnabl, Susanne, Quiroga, Maite P., Sivina, Mariela, Wierda, William G., Estrov, Zeev, Keating, Michael J., Shehata, Medhat, Jäger, Ulrich, Gandhi, Varsha, Kay, Neil E., Plunkett, William, Burger, Jan A.
Publicat 2009

Achieving complete remission in CLL patients treated with ibrutinib: clinical significance and predictive factors

per Strati, Paolo, Schlette, Ellen J., Solis Soto, Luisa M., Duenas, Daniela E., Sivina, Mariela, Kim, Ekaterina, Keating, Michael J., Wierda, William G., Ferrajoli, Alessandra, Kantarjian, Hagop, Estrov, Zeev, Jain, Nitin, Thompson, Philip A., Wistuba, Ignacio I., Burger, Jan A.
Publicat a Blood (2020)