The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

In lymphocytes, the phosphoinositide 3′-kinase (PI3K) isoform p110δ (PI3Kδ) transmits signals from surface receptors, including the B-cell receptor (BCR). CAL-101, a selective inhibitor of PI3Kδ, displays clinical activity in CLL, causing rapid lymph node shrinkage and a transient lymphocytosis. Inh...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Hoellenriegel, Julia, Meadows, Sarah A., Sivina, Mariela, Wierda, William G., Kantarjian, Hagop, Keating, Michael J., Giese, Neill, O'Brien, Susan, Yu, Albert, Miller, Langdon L., Lannutti, Brian J., Burger, Jan A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916562/
https://ncbi.nlm.nih.gov/pubmed/21803855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-352492
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