B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406

Antigenic stimulation through the B-cell antigen receptor (BCR) is considered to promote the expansion of chronic lymphocytic leukemia (CLL) B cells. The spleen tyrosine kinase (Syk), a key component of BCR signaling, can be blocked by R406, a small-molecule Syk inhibitor, that displayed activity in...

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Veröffentlicht in:Blood
Hauptverfasser: Quiroga, Maite P., Balakrishnan, Kumudha, Kurtova, Antonina V., Sivina, Mariela, Keating, Michael J., Wierda, William G., Gandhi, Varsha, Burger, Jan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2009
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916941/
https://ncbi.nlm.nih.gov/pubmed/19491390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-212837
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