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Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells

Intrinsic and extrinsic apoptotic pathways converge to activate common downstream executioner caspases (caspase-3, -6, and -7), resulting in cell death. In chronic lymphocytic leukemia (CLL), neoplastic B cells evade apoptosis owing to the overexpression of survival proteins. We hypothesized that di...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Patel, Viralkumar, Balakrishnan, Kumudha, Keating, Michael J., Wierda, William G., Gandhi, Varsha
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326772/
https://ncbi.nlm.nih.gov/pubmed/25538042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-546796
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