Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells

Purine nucleoside phosphorylase (PNP) deficiency in humans results in T lymphocytopenia. Forodesine, a potent inhibitor of PNP, was designed based on the transition-state structure stabilized by the enzyme. Previous studies established that forodesine in the presence of deoxyguanosine (dGuo) inhibit...

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Autors principals: Balakrishnan, Kumudha, Nimmanapalli, Ramadevi, Ravandi, Farhad, Keating, Michael J., Gandhi, Varsha
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2006
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895565/
https://ncbi.nlm.nih.gov/pubmed/16778146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-007468
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