Selective, novel Spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B cell activation and migration

Syk is a protein tyrosine kinase that couples B-cell receptor (BCR) activation with downstream signaling pathways, affecting cell survival and proliferation. Moreover, Syk is involved in BCR-independent functions, such as B cell migration and adhesion. In CLL, Syk becomes activated by external signa...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Hoellenriegel, Julia, Coffey, Greg P., Sinha, Uma, Pandey, Anjali, Sivina, Mariela, Ferrajoli, Alessandra, Ravandi, Farhad, Wierda, William G., O’Brien, Susan, Keating, Michael J., Burger, Jan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459370/
https://ncbi.nlm.nih.gov/pubmed/22362000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.24
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