Selective, novel Spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B cell activation and migration

Syk is a protein tyrosine kinase that couples B-cell receptor (BCR) activation with downstream signaling pathways, affecting cell survival and proliferation. Moreover, Syk is involved in BCR-independent functions, such as B cell migration and adhesion. In CLL, Syk becomes activated by external signa...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Leukemia
Hlavní autoři: Hoellenriegel, Julia, Coffey, Greg P., Sinha, Uma, Pandey, Anjali, Sivina, Mariela, Ferrajoli, Alessandra, Ravandi, Farhad, Wierda, William G., O’Brien, Susan, Keating, Michael J., Burger, Jan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459370/
https://ncbi.nlm.nih.gov/pubmed/22362000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.24
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky