The PI3-Kinase Delta Inhibitor Idelalisib (GS-1101) Targets Integrin-Mediated Adhesion of Chronic Lymphocytic Leukemia (CLL) Cell to Endothelial and Marrow Stromal Cells

CLL cell trafficking between blood and tissue compartments is an integral part of the disease process. Idelalisib, a phosphoinositide 3-kinase delta (PI3Kδ) inhibitor causes rapid lymph node shrinkage, along with an increase in lymphocytosis, prior to inducing objective responses in CLL patients. Th...

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Main Authors: Fiorcari, Stefania, Brown, Wells S., McIntyre, Bradley W., Estrov, Zeev, Maffei, Rossana, O’Brien, Susan, Sivina, Mariela, Hoellenriegel, Julia, Wierda, William G., Keating, Michael J., Ding, Wei, Kay, Neil E., Lannutti, Brian J., Marasca, Roberto, Burger, Jan A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871531/
https://ncbi.nlm.nih.gov/pubmed/24376763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083830
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