Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

Marrow stromal cells (MSCs) provide important survival and drug resistance signals to chronic lymphocytic leukemia (CLL) cells, but current models to analyze CLL–MSC interactions are heterogeneous. Therefore, we tested different human and murine MSC lines and primary human MSCs for their ability to...

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Bibliographic Details
Main Authors: Kurtova, Antonina V., Balakrishnan, Kumudha, Chen, Rong, Ding, Wei, Schnabl, Susanne, Quiroga, Maite P., Sivina, Mariela, Wierda, William G., Estrov, Zeev, Keating, Michael J., Shehata, Medhat, Jäger, Ulrich, Gandhi, Varsha, Kay, Neil E., Plunkett, William, Burger, Jan A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081374/
https://ncbi.nlm.nih.gov/pubmed/19762485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-233718
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