Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells

OBJECTIVES: To compare the potency, toxicity and mechanism of action of multiple histone deacetylase inhibitors (HDACi) in activating HIV production from latency. DESIGN: In-vitro analysis of HDACi in a primary T-cell model of HIV latency and latently infected cell lines. METHODS: Latently infected...

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Autori principali: Wightman, Fiona, Lu, Hao K., Solomon, Ajantha E., Saleh, Suha, Harman, Andrew N., Cunningham, Anthony L., Gray, Lachlan, Churchill, Melissa, Cameron, Paul U., Dear, Anthony E., Lewin, Sharon R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079759/
https://ncbi.nlm.nih.gov/pubmed/24189584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000067
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