Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure

Abstract Background The development of heart failure is accompanied by complex changes in cardiac electrophysiology and functional properties of cardiomyocytes and fibroblasts. Histone deacetylase (HDAC) inhibitors hold great promise for the pharmaceutical therapy of several malignant diseases. Here...

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Main Authors: Johanna K. Freundt, Gerrit Frommeyer, Tilmann Spieker, Fabian Wötzel, Jochen Schulze Grotthoff, Jörg Stypmann, Georg Hempel, Michael Schäfers, Andreas H. Jacobs, Lars Eckardt, Philipp S. Lange
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-03-01
Colecção:BMC Pharmacology and Toxicology
Assuntos:
HDAC
Entinostat
Arrhythmias
Remodeling
Fibrosis
Acesso em linha:http://link.springer.com/article/10.1186/s40360-019-0294-x
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