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The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells
Dietary overload of toxic, free metabolic intermediates leads to disrupted insulin signalling and fatty liver disease. However, it was recently reported that this pathway might not be universal: depletion of histone deacetylase (HDAC) enhances insulin sensitivity alongside hepatic lipid accumulation...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4913258/ https://ncbi.nlm.nih.gov/pubmed/27320682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28025 |
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