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Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells

1,2-unsaturated pyrrolizidine alkaloids (PAs) are secondary plant metabolites occurring as food contaminants that can cause severe liver damage upon metabolic activation in hepatocytes. However, it is yet unknown how these contaminants enter the cells. The role of hepatic transporters is only at the...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Enge, Anne-Margarethe, Kaltner, Florian, Gottschalk, Christoph, Braeuning, Albert, Hessel-Pras, Stefanie
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067754/
https://ncbi.nlm.nih.gov/pubmed/33917053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22083821
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