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Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure

BACKGROUND: The development of heart failure is accompanied by complex changes in cardiac electrophysiology and functional properties of cardiomyocytes and fibroblasts. Histone deacetylase (HDAC) inhibitors hold great promise for the pharmaceutical therapy of several malignant diseases. Here, we des...

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Dades bibliogràfiques
Publicat a:BMC Pharmacol Toxicol
Autors principals: Freundt, Johanna K., Frommeyer, Gerrit, Spieker, Tilmann, Wötzel, Fabian, Grotthoff, Jochen Schulze, Stypmann, Jörg, Hempel, Georg, Schäfers, Michael, Jacobs, Andreas H., Eckardt, Lars, Lange, Philipp S.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404297/
https://ncbi.nlm.nih.gov/pubmed/30841920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-019-0294-x
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