Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the α cardiac myosin heavy chain gene

Heterozygous mice bearing an Arg403Gln missense mutation in the α cardiac myosin heavy chain gene (α-MHC(403/+)) exhibit the histopathologic features of human familial hypertrophic cardiomyopathy. Surprisingly, homozygous α-MHC(403/403) mice die by postnatal day 8. Here we report that neonatal letha...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Fatkin, Diane, Christe, Michael E., Aristizabal, Orlando, McConnell, Bradley K., Srinivasan, Shardha, Schoen, Frederick J., Seidman, Christine E., Turnbull, Daniel H., Seidman, J.G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 1999
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Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC407864/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9884344/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4631
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