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Cell-Intrinsic Functional Effects of the α-Cardiac Myosin Arg-403-Gln Mutation in Familial Hypertrophic Cardiomyopathy

Human familial hypertrophic cardiomyopathy is the most common Mendelian cardiovascular disease worldwide. Among the most severe presentations of the disease are those in families heterozygous for the mutation R403Q in β-cardiac myosin. Mice heterozygous for this mutation in the α-cardiac myosin isof...

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Autori principali: Chuan, Peiying, Sivaramakrishnan, Sivaraj, Ashley, Euan A., Spudich, James A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379014/
https://ncbi.nlm.nih.gov/pubmed/22735528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.04.049
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