Functional Effects of the Hypertrophic Cardiomyopathy R403Q Mutation Are Different in an α- or β-Myosin Heavy Chain Backbone

Eitemau Tebyg

• Hypertrophic cardiomyopathy R403Q mutation in rabbit β-myosin reduces contractile function at the molecular and myofibrillar levels
  gan: Lowey, Susan, et al.
  Cyhoeddwyd: (2018)
• The R403Q Myosin Mutation Implicated in Familial Hypertrophic Cardiomyopathy Causes Disorder at the Actomyosin Interface
  gan: Volkmann, Niels, et al.
  Cyhoeddwyd: (2007)
• Transgenic Mouse α- and β-Cardiac Myosins Containing the R403Q Mutation Show Isoform-dependent Transient Kinetic Differences
  gan: Lowey, Susan, et al.
  Cyhoeddwyd: (2013)
• Loss or Gain: Myosin Heavy Chain Truncations in Hypertrophic Cardiomyopathy
  gan: Soumojit Pal, et al.
  Cyhoeddwyd: (2025-11-01)
• The cardiac myosin heavy chain Arg-403-->Gln mutation that causes hypertrophic cardiomyopathy does not affect the actin- or ATP-binding capacities of two size-limited recombinant myosin heavy chain fragments.
  gan: Eldin, P, et al.
  Cyhoeddwyd: (1995)