Functional Effects of the Hypertrophic Cardiomyopathy R403Q Mutation Are Different in an α- or β-Myosin Heavy Chain Backbone

The R403Q mutation in the β-myosin heavy chain (MHC) was the first mutation to be linked to familial hypertrophic cardiomyopathy (FHC), a primary disease of heart muscle. The initial studies with R403Q myosin, isolated from biopsies of patients, showed a large decrease in myosin motor function, lead...

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Bibliographic Details
Main Authors: Lowey, Susan, Lesko, Leanne M., Rovner, Arthur S., Hodges, Alex R., White, Sheryl L., Low, Robert B., Rincon, Mercedes, Gulick, James, Robbins, Jeffrey
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2459289/
https://ncbi.nlm.nih.gov/pubmed/18480046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800554200
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