Transgenic Mouse α- and β-Cardiac Myosins Containing the R403Q Mutation Show Isoform-dependent Transient Kinetic Differences

Familial hypertrophic cardiomyopathy (FHC) is a major cause of sudden cardiac death in young athletes. The discovery in 1990 that a point mutation at residue 403 (R403Q) in the β-myosin heavy chain (MHC) caused a severe form of FHC was the first of many demonstrations linking FHC to mutations in mus...

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Bibliographic Details
Main Authors: Lowey, Susan, Bretton, Vera, Gulick, James, Robbins, Jeffrey, Trybus, Kathleen M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663502/
https://ncbi.nlm.nih.gov/pubmed/23580644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.450668
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