Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the α cardiac myosin heavy chain gene

Heterozygous mice bearing an Arg403Gln missense mutation in the α cardiac myosin heavy chain gene (α-MHC(403/+)) exhibit the histopathologic features of human familial hypertrophic cardiomyopathy. Surprisingly, homozygous α-MHC(403/403) mice die by postnatal day 8. Here we report that neonatal letha...

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Publicado en:	J Clin Invest
Autores principales:	Fatkin, Diane, Christe, Michael E., Aristizabal, Orlando, McConnell, Bradley K., Srinivasan, Shardha, Schoen, Frederick J., Seidman, Christine E., Turnbull, Daniel H., Seidman, J.G.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1999
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC407864/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9884344/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI4631
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