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Aggregation Behavior of Chemically Synthesized, Full-Length Huntingtin Exon1

[Image: see text] Repeat length disease thresholds vary among the 10 expanded polyglutamine (polyQ) repeat diseases, from about 20 to about 50 glutamine residues. The unique amino acid sequences flanking the polyQ segment are thought to contribute to these repeat length thresholds. The specific port...

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Bibliographische Detailangaben
Hauptverfasser: Sahoo, Bankanidhi, Singer, David, Kodali, Ravindra, Zuchner, Thole, Wetzel, Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075985/
https://ncbi.nlm.nih.gov/pubmed/24921664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500300c
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