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CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells
AIM: To examine whether CYP3A4 overexpression influences the metabolism of anticancer agent imidazoacridinone C-1311 in CHO cells and the responses of the cells to C-1311. METHODS: Wild type CHO cells (CHO-WT), CHO cells overexpressing cytochrome P450 reductase (CPR) [CHO-HR] and CHO cells coexpress...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Nature Publishing Group
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4075741/ https://ncbi.nlm.nih.gov/pubmed/24292379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.132 |
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