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CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells

AIM: To examine whether CYP3A4 overexpression influences the metabolism of anticancer agent imidazoacridinone C-1311 in CHO cells and the responses of the cells to C-1311. METHODS: Wild type CHO cells (CHO-WT), CHO cells overexpressing cytochrome P450 reductase (CPR) [CHO-HR] and CHO cells coexpress...

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書誌詳細
主要な著者: Pawłowska, Monika, Augustin, Ewa, Mazerska, Zofia
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075741/
https://ncbi.nlm.nih.gov/pubmed/24292379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.132
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