A Cryptic Polyreactive Antibody Recognizes Distinct Clades of HIV-1 Glycoprotein 120 by an Identical Binding Mechanism

Polyreactive antibodies play an important role for neutralization of human immunodeficiency virus (HIV). In addition to intrinsic polyreactive antibodies, the immune system of healthy individuals contains antibodies with cryptic polyreactivity. These antibodies acquire promiscuous antigen binding po...

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Main Authors: Dimitrov, Jordan D., Planchais, Cyril, Scheel, Tobias, Ohayon, Delphine, Mesnage, Stephane, Berek, Claudia, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067210/
https://ncbi.nlm.nih.gov/pubmed/24802758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.556266
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