A Cryptic Polyreactive Antibody Recognizes Distinct Clades of HIV-1 Glycoprotein 120 by an Identical Binding Mechanism

Polyreactive antibodies play an important role for neutralization of human immunodeficiency virus (HIV). In addition to intrinsic polyreactive antibodies, the immune system of healthy individuals contains antibodies with cryptic polyreactivity. These antibodies acquire promiscuous antigen binding po...

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Hlavní autoři: Dimitrov, Jordan D., Planchais, Cyril, Scheel, Tobias, Ohayon, Delphine, Mesnage, Stephane, Berek, Claudia, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067210/
https://ncbi.nlm.nih.gov/pubmed/24802758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.556266
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