Prevalence and Gene Characteristics of Antibodies with Cofactor-induced HIV-1 Specificity

The healthy immune repertoire contains a fraction of antibodies that bind to various biologically relevant cofactors, including heme. Interaction of heme with some antibodies results in induction of new antigen binding specificities and acquisition of binding polyreactivity. In vivo, extracellular h...

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Udgivet i:J Biol Chem
Main Authors: Lecerf, Maxime, Scheel, Tobias, Pashov, Anastas D., Jarossay, Annaelle, Ohayon, Delphine, Planchais, Cyril, Mesnage, Stephane, Berek, Claudia, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien, Dimitrov, Jordan D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335253/
https://ncbi.nlm.nih.gov/pubmed/25564611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.618124
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