Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody

Geographical expansion and re-emerging new genotypes of the Japanese encephalitis virus (JEV) require the development of novel therapeutic approaches. Here, we studied a non-conventional approach for antibody therapy and show that, upon exposure to heme, a fraction of natural human immunoglobulins a...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Gupta, Nimesh, de Wispelaere, Mélissanne, Lecerf, Maxime, Kalia, Manjula, Scheel, Tobias, Vrati, Sudhanshu, Berek, Claudia, Kaveri, Srinivas V., Desprès, Philippe, Lacroix-Desmazes, Sébastien, Dimitrov, Jordan D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635365/
https://ncbi.nlm.nih.gov/pubmed/26542535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16248
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