A Cryptic Polyreactive Antibody Recognizes Distinct Clades of HIV-1 Glycoprotein 120 by an Identical Binding Mechanism

Polyreactive antibodies play an important role for neutralization of human immunodeficiency virus (HIV). In addition to intrinsic polyreactive antibodies, the immune system of healthy individuals contains antibodies with cryptic polyreactivity. These antibodies acquire promiscuous antigen binding po...

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Bibliographic Details
Main Authors: Dimitrov, Jordan D., Planchais, Cyril, Scheel, Tobias, Ohayon, Delphine, Mesnage, Stephane, Berek, Claudia, Kaveri, Srinivas V., Lacroix-Desmazes, Sébastien
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067210/
https://ncbi.nlm.nih.gov/pubmed/24802758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.556266
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