Multiple Sclerosis Autoantigen Myelin Basic Protein Escapes Control by Ubiquitination during Proteasomal Degradation

The vast majority of cellular proteins are degraded by the 26S proteasome after their ubiquitination. Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a ubiquitin-independent manner both in vitro a...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Belogurov, Alexey, Kudriaeva, Anna, Kuzina, Ekaterina, Smirnov, Ivan, Bobik, Tatyana, Ponomarenko, Natalia, Kravtsova-Ivantsiv, Yelena, Ciechanover, Aaron, Gabibov, Alexander
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067209/
https://ncbi.nlm.nih.gov/pubmed/24739384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544247
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki