Multiple Sclerosis Autoantigen Myelin Basic Protein Escapes Control by Ubiquitination during Proteasomal Degradation

The vast majority of cellular proteins are degraded by the 26S proteasome after their ubiquitination. Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a ubiquitin-independent manner both in vitro a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Belogurov, Alexey, Kudriaeva, Anna, Kuzina, Ekaterina, Smirnov, Ivan, Bobik, Tatyana, Ponomarenko, Natalia, Kravtsova-Ivantsiv, Yelena, Ciechanover, Aaron, Gabibov, Alexander
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Protein Synthesis and Degradation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067209/
https://ncbi.nlm.nih.gov/pubmed/24739384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544247
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