Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells

Nonhomologous end-joining (NHEJ) is a key pathway for efficient repair of DNA double-strand breaks (DSBs) and V(D)J recombination. NHEJ defects in humans cause immunodeficiency and increased cellular sensitivity to ionizing irradiation (IR) and are variably associated with growth retardation, microc...

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Autors principals: Felgentreff, Kerstin, Du, Likun, Weinacht, Katja G., Dobbs, Kerry, Bartish, Margarita, Giliani, Silvia, Schlaeger, Thorsten, DeVine, Alexander, Schambach, Axel, Woodbine, Lisa J., Davies, Graham, Baxi, Sachin N., van der Burg, Mirjam, Bleesing, Jack, Gennery, Andrew, Manis, John, Pan-Hammarström, Qiang, Notarangelo, Luigi D.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066476/
https://ncbi.nlm.nih.gov/pubmed/24889605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323649111
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