Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells

Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID). The initial lesions in the switch (S) regions are subsequently processed and resolved, leading to recombination...

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Detalhes bibliográficos
Main Authors: Pan-Hammarström, Qiang, Jones, Anne-Marie, Lähdesmäki, Aleksi, Zhou, Wei, Gatti, Richard A., Hammarström, Lennart, Gennery, Andrew R., Ehrenstein, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212791/
https://ncbi.nlm.nih.gov/pubmed/15657289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040772
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