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Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells
Immunoglobulin heavy chain class switch recombination (CSR) is believed to occur through the generation and repair of DNA double-strand breaks (DSBs) in the long and repetitive switch regions. Although implied, the role of the major vertebrate DSB repair pathway, nonhomologous end joining (NHEJ), in...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585838/ https://ncbi.nlm.nih.gov/pubmed/19001141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081623 |
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