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Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination

Nonhomologous end-joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in mammals and resolves the DSBs generated during both V(D)J recombination in developing lymphocytes and class switch recombination (CSR) in antigen-stimulated B cells. In contrast to the absolute requirement...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Masani, Shahnaz, Han, Li, Meek, Katheryn, Yu, Kefei
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747719/
https://ncbi.nlm.nih.gov/pubmed/26787901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521630113
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