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Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination
Nonhomologous end-joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in mammals and resolves the DSBs generated during both V(D)J recombination in developing lymphocytes and class switch recombination (CSR) in antigen-stimulated B cells. In contrast to the absolute requirement...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747719/ https://ncbi.nlm.nih.gov/pubmed/26787901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521630113 |
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