Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

OBJECTIVE: Focal adhesion kinase (FAK) is overexpressed in serous ovarian cancer. Loss of merlin, a product of the neurofibromatosis 2 tumor suppressor gene, is being evaluated as a biomarker for FAK inhibitor sensitivity in mesothelioma. Connections between merlin and FAK in ovarian cancer remain u...

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Autors principals: Shah, Nina R., Tancioni, Isabelle, Ward, Kristy K., Lawson, Christine, Chen, Xiao Lei, Jean, Christine, Sulzmaier, Florian J., Uryu, Sean, Miller, Nichol L.G., Connolly, Denise C., Schlaepfer, David D.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065804/
https://ncbi.nlm.nih.gov/pubmed/24786638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2014.04.044
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