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Synergistic interaction between genetics and disease on pravastatin disposition

BACKGROUND & AIMS: A genome wide association study and multiple pharmacogenetic studies have implicated the hepatic uptake transporter organic anion transporting polypeptide-1B1 (OATP1B1) in the pharmacokinetics and musculoskeletal toxicity of statin drugs. Other OATP uptake transporters can par...

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Bibliografische gegevens
Hoofdauteurs: Clarke, John D., Hardwick, Rhiannon N., Lake, April D., Lickteig, Andrew J., Goedken, Michael J., Klaassen, Curtis D., Cherrington, Nathan J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065643/
https://ncbi.nlm.nih.gov/pubmed/24613363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.02.021
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