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Interaction of Oatp1b2 Expression and Nonalcoholic Steatohepatitis on Pravastatin Plasma Clearance
The downregulation of hepatic uptake transporters, including those of the OATP family, are a well known consequence of nonalcoholic steatohepatitis (NASH). Prior studies have shown that the combination of NASH and Oatp1b2 knockout synergistically reduces the clearance of pravastatin (PRAV) in the me...
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| Publicado no: | Biochem Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7058100/ https://ncbi.nlm.nih.gov/pubmed/31881192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.113780 |
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