Analysis of BRCA2 loss-of-heterozygosity in tumor tissue using droplet digital PCR

Loss-of-heterozygosity (LOH) analysis of archival tumor tissue can aid in determining the clinical significance of BRCA variants. Here we describe an approach for assessing LOH in formalin fixed paraffin embedded (FFPE) tissues using variant specific probes and droplet digital PCR (ddPCR). We evalua...

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Autors principals: Cochran, Rory L., Cravero, Karen, Chu, David, Erlanger, Bracha, Toro, Patricia Valda, Beaver, Julia A., Zabransky, Daniel J., Wong, Hong Yuen, Cidado, Justin, Croessmann, Sarah, Parsons, Heather, Kim, Minsoo, Wheelan, Sarah J., Argani, Pedram, Ho Park, Ben
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065621/
https://ncbi.nlm.nih.gov/pubmed/24824029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humpath.2014.03.013
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