Analysis of BRCA2 loss-of-heterozygosity in tumor tissue using droplet digital PCR

Loss-of-heterozygosity (LOH) analysis of archival tumor tissue can aid in determining the clinical significance of BRCA variants. Here we describe an approach for assessing LOH in formalin fixed paraffin embedded (FFPE) tissues using variant specific probes and droplet digital PCR (ddPCR). We evalua...

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Main Authors: Cochran, Rory L., Cravero, Karen, Chu, David, Erlanger, Bracha, Toro, Patricia Valda, Beaver, Julia A., Zabransky, Daniel J., Wong, Hong Yuen, Cidado, Justin, Croessmann, Sarah, Parsons, Heather, Kim, Minsoo, Wheelan, Sarah J., Argani, Pedram, Ho Park, Ben
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065621/
https://ncbi.nlm.nih.gov/pubmed/24824029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humpath.2014.03.013
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