Analysis of BRCA2 loss-of-heterozygosity in tumor tissue using droplet digital PCR

Loss-of-heterozygosity (LOH) analysis of archival tumor tissue can aid in determining the clinical significance of BRCA variants. Here we describe an approach for assessing LOH in formalin fixed paraffin embedded (FFPE) tissues using variant specific probes and droplet digital PCR (ddPCR). We evalua...

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Hlavní autoři: Cochran, Rory L., Cravero, Karen, Chu, David, Erlanger, Bracha, Toro, Patricia Valda, Beaver, Julia A., Zabransky, Daniel J., Wong, Hong Yuen, Cidado, Justin, Croessmann, Sarah, Parsons, Heather, Kim, Minsoo, Wheelan, Sarah J., Argani, Pedram, Ho Park, Ben
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065621/
https://ncbi.nlm.nih.gov/pubmed/24824029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humpath.2014.03.013
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