The I-TevI Nuclease and Linker Domains Contribute to the Specificity of Monomeric TALENs

Precise genome editing in complex genomes is enabled by engineered nucleases that can be programmed to cleave in a site-specific manner. Here, we fused the small, sequence-tolerant monomeric nuclease domain from the homing endonuclease I-TevI to transcription-like activator effectors (TALEs) to crea...

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Bibliografske podrobnosti
Main Authors: Kleinstiver, Benjamin P., Wang, Li, Wolfs, Jason M., Kolaczyk, Tomasz, McDowell, Brendon, Wang, Xu, Schild-Poulter, Caroline, Bogdanove, Adam J., Edgell, David R.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2014
Teme:
Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065259/
https://ncbi.nlm.nih.gov/pubmed/24739648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.114.011445
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