Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions

GGGGCC repeat expansions of C9orf72 represent the most common genetic variant of amyotrophic lateral sclerosis and frontotemporal degeneration, but the mechanism of pathogenesis is unclear. Recent reports have suggested that the transcribed repeat might form toxic RNA foci that sequester various RNA...

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Bibliographische Detailangaben
Hauptverfasser: Cooper-Knock, Johnathan, Walsh, Matthew J., Higginbottom, Adrian, Robin Highley, J., Dickman, Mark J., Edbauer, Dieter, Ince, Paul G., Wharton, Stephen B., Wilson, Stuart A., Kirby, Janine, Hautbergue, Guillaume M., Shaw, Pamela J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065024/
https://ncbi.nlm.nih.gov/pubmed/24866055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu120
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